A microbiome study to explore the gut-skin axis in hidradenitis suppurativa
نویسندگان
چکیده
Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory disease of the hair follicle which mainly affects intertriginous skin areas by formation nodules, sinus tracts and abscesses. Although dysbiosis cutaneous microbiome apparent in HS [ [1] Ring H.C. Thorsen J. Saunte D.M. Lilje B. Bay L. Riis P.T. et al. The follicular patients with hidradenitis healthy controls. JAMA Dermatol. 2017; 153: 897-905 Crossref PubMed Scopus (136) Google Scholar ], pathogenesis this debilitating not fully understood. concurrent existence gut diseases has led to postulation gut-skin axis microbiota are thought be involved. Bacterial metabolites entering circulation or bacterial shaping immune- neuroendocrine systems may part complex communication between [2] Salem I. Ramser A. Isham N. Ghannoum M.A. as major regulator Axis. Front. Microbiol. 2018; 9: 1459 (145) ]. Considering these potential systemic effects, perturbation might exert negative effects at distant sites. Fecal microbial alterations were demonstrated psoriasis [3] Hidalgo-Cantabrana C. Gomez Delgado S. Requena-Lopez Queiro-Silva R. Margolles Gut cohort psoriasis. Br. 2019; but communities have been explored HS. Here, we investigated fecal signatures patients.
منابع مشابه
Hidradenitis suppurativa.
BACKGROUND Hidradenitis suppurativa is a chronic, recurrent, suppurative cutaneous disease. Despite its incidence, optimal medical or surgical treatment remains unclear. This review describes the disease, ranging from pathogenesis to treatment and prognosis. METHODS Articles were sourced from PubMed and Medline, using the MeSH terms 'hidradenitis suppurativa' and 'acne inversa'. Selection of ...
متن کاملHidradenitis suppurativa.
Hidradenitis suppurativa is a chronic, relapsing, inflammatory disease process that primarily involves the axilla and/or inguinal region and does not manifest itself until after puberty. Typically, the process begins as a local occlusive disease of a sweat gland; secondary bacterial infection then occurs. The early stages of hidradenitis suppurativa are usually managed by the dermatologist. Onc...
متن کاملA family study of hidradenitis suppurativa.
A family study of hidradenitis suppurativa was undertaken based on 26 subjects with the disease. The probands were obtained from Hospital Activity Analysis (HAA) records for a three year period (1980 to 1983) and by direct referral from hospital specialists over a six month period (1983 to 1984). Family pedigree information was collected by home visits or hospital interviews and confirmation of...
متن کاملHidradenitis suppurativa
Hidradenitis suppurativa is a chronic disease characterized by recurrent, painful, deep-seated, rounded nodules and abscesses of apocrine gland-bearing skin. Subsequent suppuration, sinus tracts and hypertrophic scarring are its main features. Onset is usually after puberty, although it is most common during the third decade and may persist in old age. The disease tends to be chronic and may de...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Dermatological Science
سال: 2021
ISSN: ['0923-1811', '1873-569X']
DOI: https://doi.org/10.1016/j.jdermsci.2020.12.008